Compartment-style schematic of the within-host model.

Strain-specific variables (infected RBCs, merozoites, gametocytes, and adaptive immunity) are color-coded, with variables relating to drug-sensitive and drug-resistant parasites shown in blue and red, respectively. Non-strain-specific variables (uninfected RBCs, innate immunity) are shown in white. Solid arrows indicate that one component increases or feeds into another, while dotted arrows indicate that one component reduces another. RBC, red blood cell.