Parasitemia in C57BL/6 and CD28KO mice during primary and secondary <i>Pc</i> infections.

(a) Parasitemia curves in mice infected intraperitoneally (i.p.) with 1 x 106 Pc-iRBCs. (b) The experimental design for the secondary infections. Reminiscent parasitemia was eliminated by treating 31 to 38 days post-infection (p.i.) mice with chloroquine (CQ). At days 40 (c40) or 80 (c80) p.i., mice were challenged with 1 x 108 Pc-iRBC. Experimental analyses were performed when indicated (&). (c) Parasitemia curves after secondary infection in c40 mice and age-matched controls (0d). (d) Parasitemia curves after secondary infection in c80 mice and age-matched controls (0d). In a, c and d, the significant differences (*p<0.05, **p<0.01, ***p<0.001) between the indicated groups are shown. Data from three independent experiments (n = 5–7, mean ± standard error mean—SEM) is shown.