B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>‑Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane
- Zhentao Pan (5741510)
- Leixin Shen (5741513)
- Dingguo Song (5741516)
- Zhen Xie (519905)
- Fei Ling (146901)
- Weihui Zhong (598878)
Publication date
September 2018
DOI Publisher
American Chemical Society (ACS)Abstract
The first example of metal-free B(C6F5)3-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81–95% yield with 80–99% de. This protocol was further applied in the total synthesis of cinacalcet
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