Practical, solvent-free, one-pot synthesis of C2-symmetrical secondary amines
- Alexakis, Alexandre
- Gille, Segolene
- Prian, Fabrice
- Rosset, Stéphane
- Ditrich, Klaus
Publication date
January 2004
DOI Publisher
Elsevier BV ISSN
0040-4039 Citation count (estimate)
39Abstract
A novel one-pot reductive amination of ketones using the combination Ti(OiPr)4/H2/Pd–C is reported. This practical procedure does not require any solvent, and affords C2-symmetrical secondary amines in high yields and excellent diastereoselectivities. A novel one-pot reductive amination of ketones using the combination Ti(OiPr)4/H2/Pd–C is reported. This practical procedure does not require any solvent and affords C2-symmetrical secondary amines in high yields and excellent diastereoselectivities
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