Summary map of appropriate <i>in silico</i> model representation of the liver.

Two criteria determine if a liver lobule representation is appropriate: Precision of describing microdosimetry and computational efficiency. Five colored maps correspond to different strengths of passive transport, increasing from left to right column. In each colored map, direction from left to right corresponds to increasing metabolism and direction from top to bottom refers to increasing active transport. Color codes the appropriate model representation: blue–BOX; red–PIPE; green–NET. Since this is a three parameter space with color, individual slices of the space are shown horizontally and the colored maps are rotated for better visualization. The conditions for the model choices are as follows: If azimuthal discrepancy is greater than 25% (A) or 100% (B), NET is appropriate (green regions). If azimuthal discrepancy is smaller than 25% (A) or 100% (B) and radial discrepancy is larger than 25% (A) or 100% (B), PIPE is appropriate (red regions). Otherwise, BOX is appropriate (blue regions). Predicted parameter domains for oxygen (“O2”) and acetaminophen (“APAP”) are marked.