Spatial maps of select steady-state quantities within the virtual liver lobule.

(A) xenobiotic concentration; (B) metabolic rate; (C) time for the xenobiotic concentration to reach half of steady-state value. Solid circles indicate the positions of individual hepatocytes in the virtual liver lobule slice. These three simulations have the same transport parameters (α = 1, β = 1/s and D = 1 × 10−6 cm2/s) and only differ in metabolism parameters (from left to middle to right column, CLint = 0.01/s, 0.1/s, 1/s, respectively).