Graphical representation of p values obtained from MLM analysis of RAD sequencing data.

Panels correspond to disease occurrence (1a, 1c) and age-of-onset (1b, 1d). For Manhattan plots (1a, 1b) the x axis corresponds to the genomic position of the autosomes and the y axis shows the −log10 of the p value. The horizontal red line corresponds to the genome-wide significance threshold of p ≤ 5 × 10−8. For regional association plots (1b, 1d) the x axis corresponds to the chromosomal position and the y axis shows the −log10 of the p value. Genes in the region are shown below (not to scale).