Challenge of vaccinated ferrets with influenza viruses.

Vaccinated or unvaccinated ferrets were infected with A/Wisconsin/67/2005 (A and B) or A/California/07/2009 (C) influenza viruses. (A-C) Ferrets were monitored daily for weight loss over an 8-day observation period. Values are average percentages of original weight plus the SEM (error bars). (D) Viral titers were determined from nasal washes infected with A/California/07/2009 and collected at days 1, 3, and 5 post-challenge. Each ferret is represented with a symbol. Lines indicate mean virus titers with the standard deviations (SD). The values for CA/09, P1, and X6 are all significant (p>0.01) compared to the values at each timepoint for X3 and Mock. CA/09 was significant compared to P1 and X6 at day 3 post-infection (p>0.05). Significance was determined using paired or unpaired t tests (*p>0.05; **p >0.01).