GSEA plot showing the down regulation of the Hippo pathway in <i>FoxO6</i>^<i>-/-</i> mandibular tissue.

A) All genes are ranked based on fold change between FoxO6 null and wild type mandible and maxilla tissue, with most up regulated genes (red color) in the left and most down regulated genes (blue color) in the right. Each black line represents a gene in the Hippo pathway. As shown in this figure, Hippo pathway genes tends to located in the right (down regulated) region. B) A volcano plot showing multiple genes regulated by FoxO6, both increased and decreased expression (4 biological replicates of WT and FoxO6 mutant embryos were combined to yield the bioinformatics data).