Additional file 2: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Additional file 4: Table S4. of Exosomes isolated from cancer patientsâ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Mohamed Abdouh (181282)
Dana Hamam (3400181)
Zu-Hua Gao (329479)
Vincenzo Arena (3400187)
Manuel Arena (3400178)
Goffredo Arena (3400184)

August 2017

List of top 100 proteins that are often identified in exosomes (ExoCarta). (PDF 158 kb

Additional file 1: of Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells

Bethany Hannafon (3416945)
Amy Gin (6380960)
Yi-Fan Xu (1654144)
Matthew Bruns (6380963)
Cameron Calloway (3416951)
Wei-Qun Ding (637565)

February 2019

Raw and normalized fluorescent intensity data. File contains the raw and normalized fluorescent inte...

Additional file 1: of Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

Fatima Qadir (5516354)
Mohammad Aziz (240637)
Chrisdina Sari (5516351)
Hong Ma (48973)
Haiyan Dai (3036180)
Xun Wang (138298)
Dhiresh Raithatha (5516336)
Lucas Da Silva (5516342)
Muhammad Hussain (5516345)
Seyedeh Poorkasreiy (5516348)
Iain Hutchison (5516339)
Ahmad Waseem (155362)
Muy-Teck Teh (155335)

July 2018

Figure S1. RT-qPCR confirmed differential mRNA sorting into exosomes. Figure S2. Full length mRNA tr...

Additional file 9: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S8. MNI cells selection at acid pH. a Workflow of MNI selection at acid pH. At the end of acc...

Additional file 4: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S3. a MNI, and b EP cells phase contrast with bounds of the selected cells (n = 30) for each ...

Additional file 7: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S6. MNI and MI intracellular expression of exosome markers and intracellular pH (pHi) evaluat...

Additional file 12: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Table S3. pHÂ 6.0 upregulated categories involved in metastatic processes are indicated. Proteins fo...

Additional file 1: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S1. Characterization of cell lines used in this study. a Overview table depicting classificat...

Additional file 6: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S5. MNI cells labeling with CFDA-SE, vesicles isolation and FACS analysis. a MNI cells were l...

Additional file 5: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S4. TLC analysis of fluorescent lipids of MNI cells and exosomes. a Cells at the indicated pH...

Additional file 11: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Table S2. List of exosomal proteins from MNI cells identified by mass-spectrometry and found upregul...

Additional file 6: Table S6. of Exosomes isolated from cancer patientsâ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Mohamed Abdouh (181282)
Dana Hamam (3400181)
Zu-Hua Gao (329479)
Vincenzo Arena (3400187)
Manuel Arena (3400178)
Goffredo Arena (3400184)

August 2017

Exosome proteins involved in microvesicles uptake (Ligands for the receptors determined by MS on fib...

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Boussadia, Zaira
Lamberti, Jessica
Mattei, Fabrizio
Pizzi, Elisabetta
Puglisi, Rossella
Zanetti, Cristiana
Pasquini, Luca
Fratini, Federica
Fantozzi, Luca
Felicetti, Federica
Fecchi, Katia
Raggi, Carla
Sanchez, Massimo
D'Atri, Stefania
Carè, Alessandra
Sargiacomo, Massimo
Parolini, Isabella

January 2018

Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is ...

Additional file 1: of Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Cassandra Goulet (6323189)
Audrey Champagne (6323192)
Geneviève Bernard (176820)
Dominique Vandal (6323195)
Stéphane Chabaud (3797350)
Frédéric Pouliot (3738070)
Stéphane Bolduc (6323198)

February 2019

Exosomes characterization. A. TEM micrographs showing morphology of exosomes immunoprecipitated with...

Additional file 8: of Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Xu Zhang (49484)
Hui Shi (278337)
Xiao Yuan (522103)
Pengcheng Jiang (2015869)
Hui Qian (110856)
Wenrong Xu (110863)

October 2018

Figure S7. Exosomal HMGB1 expression in tumor tissues and serum samples of gastric cancer patients. ...

Additional file 4: Table S4. of Exosomes isolated from cancer patientsâ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Mohamed Abdouh (181282)
Dana Hamam (3400181)
Zu-Hua Gao (329479)
Vincenzo Arena (3400187)
Manuel Arena (3400178)
Goffredo Arena (3400184)

August 2017

List of top 100 proteins that are often identified in exosomes (ExoCarta). (PDF 158 kb

Additional file 1: of Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells

Bethany Hannafon (3416945)
Amy Gin (6380960)
Yi-Fan Xu (1654144)
Matthew Bruns (6380963)
Cameron Calloway (3416951)
Wei-Qun Ding (637565)

February 2019

Raw and normalized fluorescent intensity data. File contains the raw and normalized fluorescent inte...

Additional file 1: of Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

Fatima Qadir (5516354)
Mohammad Aziz (240637)
Chrisdina Sari (5516351)
Hong Ma (48973)
Haiyan Dai (3036180)
Xun Wang (138298)
Dhiresh Raithatha (5516336)
Lucas Da Silva (5516342)
Muhammad Hussain (5516345)
Seyedeh Poorkasreiy (5516348)
Iain Hutchison (5516339)
Ahmad Waseem (155362)
Muy-Teck Teh (155335)

July 2018

Figure S1. RT-qPCR confirmed differential mRNA sorting into exosomes. Figure S2. Full length mRNA tr...

Additional file 9: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S8. MNI cells selection at acid pH. a Workflow of MNI selection at acid pH. At the end of acc...

Additional file 4: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S3. a MNI, and b EP cells phase contrast with bounds of the selected cells (n = 30) for each ...

Additional file 7: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S6. MNI and MI intracellular expression of exosome markers and intracellular pH (pHi) evaluat...

Additional file 12: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Table S3. pHÂ 6.0 upregulated categories involved in metastatic processes are indicated. Proteins fo...

Additional file 1: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S1. Characterization of cell lines used in this study. a Overview table depicting classificat...

Additional file 6: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania D’Atri (4349572)
Alessandra Carè (380650)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S5. MNI cells labeling with CFDA-SE, vesicles isolation and FACS analysis. a MNI cells were l...

Additional file 5: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Figure S4. TLC analysis of fluorescent lipids of MNI cells and exosomes. a Cells at the indicated pH...

Additional file 11: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Zaira Boussadia (5825018)
Jessica Lamberti (5825021)
Fabrizio Mattei (415284)
Elisabetta Pizzi (80266)
Rossella Puglisi (3510983)
Cristiana Zanetti (5825024)
Luca Pasquini (168695)
Federica Fratini (4411906)
Luca Fantozzi (5825027)
Federica Felicetti (380640)
Katia Fecchi (129956)
Carla Raggi (5825030)
Massimo Sanchez (183600)
Stefania DâAtri (4349590)
Alessandra CarĂ¨ (3510971)
Massimo Sargiacomo (5825033)
Isabella Parolini (5825036)

October 2018

Table S2. List of exosomal proteins from MNI cells identified by mass-spectrometry and found upregul...

Additional file 6: Table S6. of Exosomes isolated from cancer patientsâ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Mohamed Abdouh (181282)
Dana Hamam (3400181)
Zu-Hua Gao (329479)
Vincenzo Arena (3400187)
Manuel Arena (3400178)
Goffredo Arena (3400184)

August 2017

Exosome proteins involved in microvesicles uptake (Ligands for the receptors determined by MS on fib...

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Boussadia, Zaira
Lamberti, Jessica
Mattei, Fabrizio
Pizzi, Elisabetta
Puglisi, Rossella
Zanetti, Cristiana
Pasquini, Luca
Fratini, Federica
Fantozzi, Luca
Felicetti, Federica
Fecchi, Katia
Raggi, Carla
Sanchez, Massimo
D'Atri, Stefania
Carè, Alessandra
Sargiacomo, Massimo
Parolini, Isabella

January 2018

Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is ...

Additional file 1: of Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Cassandra Goulet (6323189)
Audrey Champagne (6323192)
Geneviève Bernard (176820)
Dominique Vandal (6323195)
Stéphane Chabaud (3797350)
Frédéric Pouliot (3738070)
Stéphane Bolduc (6323198)

February 2019

Exosomes characterization. A. TEM micrographs showing morphology of exosomes immunoprecipitated with...

Additional file 8: of Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Xu Zhang (49484)
Hui Shi (278337)
Xiao Yuan (522103)
Pengcheng Jiang (2015869)
Hui Qian (110856)
Wenrong Xu (110863)

October 2018

Figure S7. Exosomal HMGB1 expression in tumor tissues and serum samples of gastric cancer patients. ...

Additional file 4: Table S4. of Exosomes isolated from cancer patientsâ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

Mohamed Abdouh (181282)
Dana Hamam (3400181)
Zu-Hua Gao (329479)
Vincenzo Arena (3400187)
Manuel Arena (3400178)
Goffredo Arena (3400184)

August 2017

List of top 100 proteins that are often identified in exosomes (ExoCarta). (PDF 158 kb

Additional file 1: of Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells

Bethany Hannafon (3416945)
Amy Gin (6380960)
Yi-Fan Xu (1654144)
Matthew Bruns (6380963)
Cameron Calloway (3416951)
Wei-Qun Ding (637565)

February 2019

Raw and normalized fluorescent intensity data. File contains the raw and normalized fluorescent inte...

Additional file 1: of Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

Fatima Qadir (5516354)
Mohammad Aziz (240637)
Chrisdina Sari (5516351)
Hong Ma (48973)
Haiyan Dai (3036180)
Xun Wang (138298)
Dhiresh Raithatha (5516336)
Lucas Da Silva (5516342)
Muhammad Hussain (5516345)
Seyedeh Poorkasreiy (5516348)
Iain Hutchison (5516339)
Ahmad Waseem (155362)
Muy-Teck Teh (155335)

July 2018

Figure S1. RT-qPCR confirmed differential mRNA sorting into exosomes. Figure S2. Full length mRNA tr...

Additional file 2: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Abstract

Extracted data

Additional file 2: of Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Abstract

Extracted data

Related items

Related items