Study design.

(A) Mice in both groups underwent ischemic injury by LAD ligation, which lasted 45 minutes, and received a single injection of either LepA 250μg in 200μl saline solution or 200μl saline alone at reperfusion. Echocardiography was performed at baseline, 24 hours and 30 days postoperatively; (B) Body weight (mean±SE) time course analysis.