Levels of sarcomeric organization in control and IsP iPSC-CM.
- Revital Schick (5866778)
- Lucy N. Mekies (5866781)
- Yuval Shemer (5866784)
- Binyamin Eisen (5866787)
- Tova Hallas (5866790)
- Ronen Ben Jehuda (5866793)
- Meital Ben-Ari (5866796)
- Agnes Szantai (5866799)
- Lubna Willi (5866802)
- Rita Shulman (5866805)
- Michael Gramlich (3387311)
- Luna Simona Pane (5866808)
- Ilaria My (5866811)
- Dov Freimark (5866814)
- Marta Murgia (5866817)
- Gianluca Santamaria (3178125)
- Mihaela Gherghiceanu (4304923)
- Michael Arad (747751)
- Alessandra Moretti (685094)
- Ofer Binah (298470)
Publication date
October 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
Panel [A] shows immunofluorescence images of α-actinin and cardiac troponin-T (cTNT) in healthy and IsP mutated single cardiomyocytes, illustrating three different levels of sarcomeric organization—fully, peripherally and perinuclear organized (upper, middle and lower panels, respectively). Panel [B] presents percentage of cells with different levels of sarcomeric organization. Statistic difference was tested using the chi-squared test Healthy (clone 24.5 n = 274), IsP (clone 23.2 n = 160, clone 23.10 n = 160, n = 320; ****P<0.001 Healthy vs IsP iPSC-CM). Scale bars = 25 μm.</p
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