Gene Ontology terms enrichment analysis of downregulated genes detected by RNA-seq in adult <i>S</i>. <i>mansoni</i> female and male worms treated with GSK343.

Top 20 enriched GO terms for differentially expressed downregulated genes in female (A) and in male (B) adult worms. The three major GO term categories, namely Biological Process, Cellular Component and Molecular Function are separately represented in each panel. The size of the circles is proportional to the number of genes in each significantly enriched category, as indicated at the lower part scales; the colors show the statistical significance of the enrichment, as indicated by the -log10 FDR values that appear in the color-coded scales at the bottom. A GO enrichment significance cutoff of FDR ≤ 0.05 was used.