Complete longitudinal analysis of the experimental infection of M04203.

The juvenile macaque M04203 was experimentally inoculated with saliva from the donor macaques as indicated in the legend to Fig 5. Blood and saliva samples were collected weekly and/or bi-weekly until the experiment was terminated 209 weeks after the initial saliva inoculation and M04203 was culled. At week 164, the animal received a course of dexamethasone treatment as indicated in the text and Fig 3. A) The RV1 genome levels were determined using the RV1 qPCR assay and the RV1 antibody levels were determined using the RV1 Luminex assay. B) the LCV genome levels were determined using the LCV qPCR assay and the LCV antibody levels were determined using the LCV Luminex assay. C) The absolute count of neutrophils, monocytes and lymphocytes was determined. D) the CD4/CD8 ratio was determined from the lymphocyte count.