Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load and glial activation in the J20 Alzheimer mouse model. Contains supplementary information and supplementary figures, belonging to the study ‘Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load and glial activation in the J20 Alzheimer mouse model’. (PDF 1866 kb
Modifications of brain TREM-2 proteins induced by ARA diet and Aβ42. Immediately after the probe tes...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Figure S2. HFD increases Aβ levels in the hippocampi of A7-Tg mice. Soluble Aβ levels in the hippoca...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
BackgroundLipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative cond...
Cerebral insulin injection to the right hippocampus. (a) 2 μl of insulin (0.05I.U) or artificial cer...
Comparative analysis of DEGs between different conditions. Table S2. Common DEGs between cortex and ...
AQP4 deficiency increased reactive astrogliosis and Aβ plaque deposits in 6.5 month-old APP/PS1 mice...
Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were norm...
Plcg2 in situ hybridization on brain tissue. A) RNAScope for PLCG2, positive (PPIB) and negative (Da...
APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Figure S2. (A) Quantification of amyloid plaque load (% of total ROI area) in male (M) and female (F...
Figure S1. Long-term exposure to HFD induces obesity, insulin resistance and hyperglycemia in A7-Tg ...
Modifications of brain TREM-2 proteins induced by ARA diet and Aβ42. Immediately after the probe tes...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Figure S2. HFD increases Aβ levels in the hippocampi of A7-Tg mice. Soluble Aβ levels in the hippoca...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
BackgroundLipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative cond...
Cerebral insulin injection to the right hippocampus. (a) 2 μl of insulin (0.05I.U) or artificial cer...
Comparative analysis of DEGs between different conditions. Table S2. Common DEGs between cortex and ...
AQP4 deficiency increased reactive astrogliosis and Aβ plaque deposits in 6.5 month-old APP/PS1 mice...
Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were norm...
Plcg2 in situ hybridization on brain tissue. A) RNAScope for PLCG2, positive (PPIB) and negative (Da...
APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Figure S2. (A) Quantification of amyloid plaque load (% of total ROI area) in male (M) and female (F...
Figure S1. Long-term exposure to HFD induces obesity, insulin resistance and hyperglycemia in A7-Tg ...
Modifications of brain TREM-2 proteins induced by ARA diet and Aβ42. Immediately after the probe tes...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...