Additional file 3: of Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreactivity of astrocytes in the cortex and hippocampus of WT mice, APN−/−mice, 5xFAD mice, and APN−/−5xFAD mice at 9 months old. Scale bar 400 μm. (b) Quantification of GFAP fluorescence intensity WT mice, APN−/−mice, 5xFAD mice, and APN−/−5xFAD mice (n = 4). One-way ANOVA with Tukey’s multiple comparison test revealed the difference between groups. **p < 0.01, ***p < 0.001; ns, statistically not significant. (TIF 3235 kb