Functional analysis of Regeneration Gene Set.

A. The plot highlights the differentially expressed genes from the “Regeneration vs No-Regeneration” comparison (blue dots) on the results of the WT-Injury vs WT-Control comparison. The Venn diagrams show the intersections between the two comparisons. B. Model based on manual inspection of regeneration genes with enriched Gene Ontology terms. Circle sizes are proportional to the number of genes contained in each category. C. Heatmap of the regeneration genes’ fold-change after injury in the different mutants and pharmacological treatments. Vertical color bar groups genes by GO term, colored as in B. Hierarchical clustering of columns was determined using the hclust function of the stats package in R, and the distance measured using a Pearson correlation and "complete" as the clustering method.