Phenotypically CD8positive B cells belong to a differentiated subpopulation characterized by CD200-CD27++.
- Ulrike Strittmatter-Keller (6078497)
- Caroline Walter (6078500)
- Celine Rauld (1697938)
- Nicole Egli (824646)
- Camille Regairaz (6078503)
- Sabine Rabe (6078506)
- Gerhard Zenke (2342968)
- José Carballido (6078509)
- Tamás Schweighoffer (6078512)
Publication date
December 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Comparison of genes expressed by CD8+ B cells, control (CTRL) CD8- B cells, and NK cells. Boxplots represent log(2) normalized data obtained from Affymetrix gene chip measurements of cells sorted from four independent apheresis donors. Differences between the B cell populations vs. NK cells are all highly significant for all genes; (x) indicates a slightly significant (p = 0.048) difference between CD8+ B and control B cells in this dataset. (B) Heatmap of the top upregulated (red) and downregulated (blue) genes on CD8+B cells in comparison to control CD8- B cells. Data represent normalized Affymetrix gene chip measurements of cells sorted from four independent apheresis donors.</p
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