Heterologous neutralization breadth of HIV-1 mAbs.
- Valentine U. Chukwuma (777423)
- Nurgun Kose (5955125)
- D. Noah Sather (106419)
- Gopal Sapparapu (411506)
- Rachel Falk (6103193)
- Hannah King (5583837)
- Vidisha Singh (6103196)
- Rebecca Lampley (6103199)
- Delphine C. Malherbe (456063)
- Noah T. Ditto (4110187)
- Jonathan T. Sullivan (243349)
- Trevor Barnes (458046)
- Benjamin J. Doranz (197292)
- Celia C. Labranche (6103202)
- David C. Montefiori (108747)
- Spyros A. Kalams (52435)
- Nancy L. Haigwood (332676)
- James E. Crowe Jr. (113691)
Publication date
December 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
The neutralization phenotypes of HIV-1 mAbs and polyclonal mixtures from subjects VC10014 and VC20013 were determined using neutralization assays against heterologous pseudoviruses from the indicated clades. The values reported here shaded in grey are the IC50 values of neutralization as antibody concentration in μg/mL. The percent breadth reported is calculated by dividing the number of pseudoviruses for which an IC50 was recorded by the total number of pseudoviruses tested and multiplying by 100.</p
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