Comparison of LR estimate versus cell-sorted estimates.

Hexagon plots of LR estimate of cell-type methylation difference on the vertical axis obtained from mixed-cell data is compared with the cell-sorted estimate of cell-type methylation difference on the horizontal axis obtained independently from cell-sorted data for all measured CpGs. The shading of the hexagonal bin indicates the density of CpGs in that bin. This comparison is made for each cell-subtype and lineage grouping.