Additional file 1: of Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

Table S1. Summary statistics for the 33 highly edited sites. Table S2. Cell composition variables associated to CES total editing rate and ADAR / ADARB1 expression level. Table S3. Phenotypic / pharmacological variables considered in the study. Table S4. Biological / pharmacological factors associated to CES total editing rate and ADARs expression. Table S5. Association of cell composition variables, biological and pharmacological variables with. The top 5 editing principal components. Table S6. Association of drug an medication intake variables with sex of subjects. Table S7. Association of ADAR and ADARB1 expression with the top 5 editing principal components. Table S8. Association with CES total editing rate for the known ADAR eQTLs. Figure S1. Measurable editing sites cover most sites in blood expressed genes. Figure S2. Distribution of sites with detectable editing. Figure S3. Concordance between editing levels and REDIPortal. Figure S4. Overlap between CES and known miRNA binding sites from TargetScan. Figure S5. Correlation of editing levels between sites. Figure S6. Correlation of ADAR and ADARB1 expression on Alu and Non-Alu editing sites. Figure S7. Linear regression models predicting ADAR / ADARB1 expression level from cell composition variables and biological variables. Figure S8. Effect of the top associated ADAR eQTL on ADAR expression and CES total editing rate. Figure S9. Distribution of the main RNA sequencing metrics for the experiments used. Figure S10. Correlation between observed editing variance and median coverage at editing sites. (PDF 1157 kb