GM5758 cells were treated with or without 1 μM NVP-BEZ235 for 1 hour prior to irradiation with 1 Gy and allowed to repair for the indicated time. Removal of 53BP1 (A) and ɣH2AX (B) foci are shown. Error bars represent the standard error of the mean from two independent experiments, and more than 50 nuclei were scored in each experiment. *p<0.05, **p<0.01.</p
<p>Average 53BP1 foci levels in a uniform (Striped) field compared with the in-field (dotted), out-o...
<p>(A) Phosphorylation of DNA-PKcs on threonine-2609 (green) in cells irradiated and incubated witho...
Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity in...
GM5758 cells were irradiated with 40 Gy gamma radiation and allowed to repair at 13°C (A), 15°C (B) ...
Human GM5758, HCT116 and HCT116 DNA-PKcs KO cell lines were pretreated one hour prior to irradiation...
<p>U2OS-shBRUCE cells with stable expression of BRUCE or BRUCE mutants as indicated to the left were...
<p>Panel a: the increase in the number of foci-positive cells (those containing greater than 10 per ...
<p>A, Example of assay for 53BP1 foci in the positive control (BJ/hTERT/SV40, blue) (top) and an ALT...
<p>Kinetics of γ-H2AX foci removal after irradiation. Non-stem and CSC-like MDA-MB-435 and MDA-MB-23...
<p>Kinetics of γ-H2AX foci removal after irradiation. Non-stem and CSC-like MDA-MB-435 and MDA-MB-23...
<p><b>A</b>, Cells were treated with TSA. At 48 h after the treatment period, the cells were exposed...
<p>U2OS-shBRUCE cells with stable expression of BRUCE or BRUCE mutants as indicated to the left were...
<p>HCT 116 cells either with p300 knocked out (p300 ko) or with those p300ko cells complimented with...
<p>U2OS-shBRUCE cells with stable expression of BRUCE or BRUCE mutants as indicated to the left were...
<p>Representative microscopic fluorescence images of γ-H2AX foci accumulation after HQ treatment for...
<p>Average 53BP1 foci levels in a uniform (Striped) field compared with the in-field (dotted), out-o...
<p>(A) Phosphorylation of DNA-PKcs on threonine-2609 (green) in cells irradiated and incubated witho...
Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity in...
GM5758 cells were irradiated with 40 Gy gamma radiation and allowed to repair at 13°C (A), 15°C (B) ...
Human GM5758, HCT116 and HCT116 DNA-PKcs KO cell lines were pretreated one hour prior to irradiation...
<p>U2OS-shBRUCE cells with stable expression of BRUCE or BRUCE mutants as indicated to the left were...
<p>Panel a: the increase in the number of foci-positive cells (those containing greater than 10 per ...
<p>A, Example of assay for 53BP1 foci in the positive control (BJ/hTERT/SV40, blue) (top) and an ALT...
<p>Kinetics of γ-H2AX foci removal after irradiation. Non-stem and CSC-like MDA-MB-435 and MDA-MB-23...
<p>Kinetics of γ-H2AX foci removal after irradiation. Non-stem and CSC-like MDA-MB-435 and MDA-MB-23...
<p><b>A</b>, Cells were treated with TSA. At 48 h after the treatment period, the cells were exposed...
<p>U2OS-shBRUCE cells with stable expression of BRUCE or BRUCE mutants as indicated to the left were...
<p>HCT 116 cells either with p300 knocked out (p300 ko) or with those p300ko cells complimented with...
<p>U2OS-shBRUCE cells with stable expression of BRUCE or BRUCE mutants as indicated to the left were...
<p>Representative microscopic fluorescence images of γ-H2AX foci accumulation after HQ treatment for...
<p>Average 53BP1 foci levels in a uniform (Striped) field compared with the in-field (dotted), out-o...
<p>(A) Phosphorylation of DNA-PKcs on threonine-2609 (green) in cells irradiated and incubated witho...
Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity in...