Figure S1. Manhattan and QQ plots showing epigenome-wide association results from secondary analysis when accounting for the rate of nicotine metabolism using a GRS. (A) QQ plot showing observed versus expected − log10(P) for association at all loci. (B) Manhattan plot showing chromosomal locations of − log10(P) for association at each locus. All CpG sites with FDR < 0.05 are highlighted in green and the top gene for each of the highlighted loci is labeled. (PDF 171 kb
Figure S1. Venn diagram of overlap in genes and non-coding RNA for three racial/ethnic groups. Figur...
Figure S1. Graphs of the CHRNA5 rs16969968 genotyping. Nucleotide changes results in different curve...
Genomic context of the CpGs associated with the significant SNPs. Each plot corresponds to a SNP for...
Table S2. SNPs in the 40 top genes significantly associated (FDR pâ<â0.05) with cotinine levels....
Table S1. Gene network (IPA) and pathway analysis (Gene Ontology) of EWAS results. (XLS 3125 kb
Table S5. Mediation analysis omnibus P values for the 19 meQTLs associated with serum cotinine level...
Table S7. CpG sites showing significant (FDR pâ<â0.05) association with cotinine levels in regul...
Table S3. Cis acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. (X...
Table S6. Transcription factor binding site information for 55 highlighted CpG sites based on ENCODE...
Figure S3. Mediation analysis to assess whether DNA methylation is a causal mediator to the observed...
Table S4. Trans acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. ...
Table S8. Results for CIT performed on DILGOM sample replicated CpG sites and SNPs associated with t...
Table S1. Haplotype of rs6495308 with lead SNPs of bin 1 (rs16969968, G > A) or bin 2 (rs1948, G > A...
Distribution of mean β-values of all X chromosomal sites in males (A) and females (B). Figure S2. Q...
Log quantile-quantile (QQ) p-value plot as a result of the genome-wide association study for the com...
Figure S1. Venn diagram of overlap in genes and non-coding RNA for three racial/ethnic groups. Figur...
Figure S1. Graphs of the CHRNA5 rs16969968 genotyping. Nucleotide changes results in different curve...
Genomic context of the CpGs associated with the significant SNPs. Each plot corresponds to a SNP for...
Table S2. SNPs in the 40 top genes significantly associated (FDR pâ<â0.05) with cotinine levels....
Table S1. Gene network (IPA) and pathway analysis (Gene Ontology) of EWAS results. (XLS 3125 kb
Table S5. Mediation analysis omnibus P values for the 19 meQTLs associated with serum cotinine level...
Table S7. CpG sites showing significant (FDR pâ<â0.05) association with cotinine levels in regul...
Table S3. Cis acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. (X...
Table S6. Transcription factor binding site information for 55 highlighted CpG sites based on ENCODE...
Figure S3. Mediation analysis to assess whether DNA methylation is a causal mediator to the observed...
Table S4. Trans acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. ...
Table S8. Results for CIT performed on DILGOM sample replicated CpG sites and SNPs associated with t...
Table S1. Haplotype of rs6495308 with lead SNPs of bin 1 (rs16969968, G > A) or bin 2 (rs1948, G > A...
Distribution of mean β-values of all X chromosomal sites in males (A) and females (B). Figure S2. Q...
Log quantile-quantile (QQ) p-value plot as a result of the genome-wide association study for the com...
Figure S1. Venn diagram of overlap in genes and non-coding RNA for three racial/ethnic groups. Figur...
Figure S1. Graphs of the CHRNA5 rs16969968 genotyping. Nucleotide changes results in different curve...
Genomic context of the CpGs associated with the significant SNPs. Each plot corresponds to a SNP for...