Figure S4. LRC cells co-labeled with typical MSC markers. In the early stages of the lesion (A&C), and proposed niche (B&D), many CldU+/IdU− (quiescent stem cells) co-labeled with Stro1(A&B) and S100A4 (C&D). A-D are on the same scale, Bar = 50 μm. (TIF 9632 kb
Additional file 1. Fig. S1 Synovitis subscores. Fig. S2 Histological evaluation of a bone marrow les...
Figure S7. Pathways enriched in genes in the upper expression quartile versus the lower expression q...
Increased endothelial marker expression during osteoblast differentiation of hiPSCs and differentiat...
Figure S10. Working model of injury-induced MSC niche. Injury-induced local microenvironment (MSC ni...
Figure S9. Characterization of candidate niche supportive ECM molecules. A) Col4 was mainly involved...
Figure S6. Conditional depletion of Glast-creERT+ cells resulted in less severe yet “typical” HO. A&...
Table S3. Summary of the histomorphometric analysis of Nse-BMP4;Glast-creERT;ROSA26-eGFP-DTA mice wi...
Figure S5. The distribution of Cre-labeled cells outside of the target regions. A&B) the distributio...
Figure S3. Validation of the dual-pulse CldU and IdU labeling procedure. To validate this procedure,...
Figure S1. Representative X-ray/CT images of 8 patients with aHO. The number in each panel is the pa...
Figure S2. Representative H&E images of 8 patients with aHO. The number in each panel is the patient...
Figure S7. Gli1-creERT-mediated DTA expression inhibited injury-induced HO. A&B) Typical x-ray image...
Figure S8. Evidence of depletion of Gli1 in the target cells. The depletion of Gli1 in the target ce...
Cell surface markers and differentiation capacities of mouse MSCs. (A) Flow cytometry analysis resul...
Abstract Background Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibr...
Additional file 1. Fig. S1 Synovitis subscores. Fig. S2 Histological evaluation of a bone marrow les...
Figure S7. Pathways enriched in genes in the upper expression quartile versus the lower expression q...
Increased endothelial marker expression during osteoblast differentiation of hiPSCs and differentiat...
Figure S10. Working model of injury-induced MSC niche. Injury-induced local microenvironment (MSC ni...
Figure S9. Characterization of candidate niche supportive ECM molecules. A) Col4 was mainly involved...
Figure S6. Conditional depletion of Glast-creERT+ cells resulted in less severe yet “typical” HO. A&...
Table S3. Summary of the histomorphometric analysis of Nse-BMP4;Glast-creERT;ROSA26-eGFP-DTA mice wi...
Figure S5. The distribution of Cre-labeled cells outside of the target regions. A&B) the distributio...
Figure S3. Validation of the dual-pulse CldU and IdU labeling procedure. To validate this procedure,...
Figure S1. Representative X-ray/CT images of 8 patients with aHO. The number in each panel is the pa...
Figure S2. Representative H&E images of 8 patients with aHO. The number in each panel is the patient...
Figure S7. Gli1-creERT-mediated DTA expression inhibited injury-induced HO. A&B) Typical x-ray image...
Figure S8. Evidence of depletion of Gli1 in the target cells. The depletion of Gli1 in the target ce...
Cell surface markers and differentiation capacities of mouse MSCs. (A) Flow cytometry analysis resul...
Abstract Background Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibr...
Additional file 1. Fig. S1 Synovitis subscores. Fig. S2 Histological evaluation of a bone marrow les...
Figure S7. Pathways enriched in genes in the upper expression quartile versus the lower expression q...
Increased endothelial marker expression during osteoblast differentiation of hiPSCs and differentiat...