Open circles, C57BL/6J mice; closed circles, RPE65−/− mice. A, Thickness changes in the inner retinal layer. B, The thickness of the outer nuclear layer. C, The thickness of the photoreceptor IS and OS layer. D, The thickness of the combined RPE and choroid layer. Statistical significance: *, P P P t-test).</p
<p>(<b>a</b>) Left: H&E staining of the whole eyeball of WT and KO mice. Scale bar = 500 μm. Squares...
<p>A. Light micrographs of Epon resin embedded retinal sections of 4-wk-old littermates. The organiz...
<p>RPE, retinal pigment epithelium; ELM/IS/OS, external limiting membrane/inner segment of photorece...
<p>Retinal thickness in nasal and temporal sides in SD-OCT image (A) and in corresponding histologic...
<p>A, changes in the thickness of the retinal sublayer A, which consists of the retinal nerve fiber ...
<p>Thicknesses are reported in mean ± SD <i>μ</i>m, statistical significance (<i>p</i> < 0.01) indic...
<p>(A-D) Exemplary total retina (TR) thickness maps extracted in an annulus of 200 <i>μm</i> width f...
<p>SD-OCT images of control mice retina (A) and <i>rho−/−</i> mice retina (B) from post-natal day 21...
To report normative data for retinal thickness in wild-type C57BL/6 mouse utilizing a miniature SD-O...
<p>(A) Representative retinal sections stained with hematoxylin and eosin demonstrate marked decreas...
<p><b>A</b>) Photographs of plastic retina sections from Rd9/Y and B6 mice at the ages indicated. Mo...
<p>The mean outer nuclear layer (ONL) of the retinas of R6/2 and wild-type (WT) mice are virtually i...
<p>H&E stained cross-sections show that the RPE membrane (arrows) is broken and the retina is thicke...
<p>The significant attenuation of retinal thickness as well as obliteration of nuclear layers in the...
<p>Each dot in the figure corresponds to the mean thickness from 10 animals and the color code repre...
<p>(<b>a</b>) Left: H&E staining of the whole eyeball of WT and KO mice. Scale bar = 500 μm. Squares...
<p>A. Light micrographs of Epon resin embedded retinal sections of 4-wk-old littermates. The organiz...
<p>RPE, retinal pigment epithelium; ELM/IS/OS, external limiting membrane/inner segment of photorece...
<p>Retinal thickness in nasal and temporal sides in SD-OCT image (A) and in corresponding histologic...
<p>A, changes in the thickness of the retinal sublayer A, which consists of the retinal nerve fiber ...
<p>Thicknesses are reported in mean ± SD <i>μ</i>m, statistical significance (<i>p</i> < 0.01) indic...
<p>(A-D) Exemplary total retina (TR) thickness maps extracted in an annulus of 200 <i>μm</i> width f...
<p>SD-OCT images of control mice retina (A) and <i>rho−/−</i> mice retina (B) from post-natal day 21...
To report normative data for retinal thickness in wild-type C57BL/6 mouse utilizing a miniature SD-O...
<p>(A) Representative retinal sections stained with hematoxylin and eosin demonstrate marked decreas...
<p><b>A</b>) Photographs of plastic retina sections from Rd9/Y and B6 mice at the ages indicated. Mo...
<p>The mean outer nuclear layer (ONL) of the retinas of R6/2 and wild-type (WT) mice are virtually i...
<p>H&E stained cross-sections show that the RPE membrane (arrows) is broken and the retina is thicke...
<p>The significant attenuation of retinal thickness as well as obliteration of nuclear layers in the...
<p>Each dot in the figure corresponds to the mean thickness from 10 animals and the color code repre...
<p>(<b>a</b>) Left: H&E staining of the whole eyeball of WT and KO mice. Scale bar = 500 μm. Squares...
<p>A. Light micrographs of Epon resin embedded retinal sections of 4-wk-old littermates. The organiz...
<p>RPE, retinal pigment epithelium; ELM/IS/OS, external limiting membrane/inner segment of photorece...