Additional file 1: of Partial-volume correction in dynamic PET-CT: effect on tumor kinetic parameter estimation and validation of simplified metrics

Table S1. Spearman correlations between IDIF AUCs of PVC-images and uncorrected images. All correlations were significant with p < 0.001. Table S2. Median relative differences (% with IQR) in K1, Vt, and k3/k4 of uncorrected images using uncorrected versus corrected IDIFs (PVC without and with HYPR denoising). *p < 0.05 Wilcoxon-signed-rank test. Table S3. Relative changes (%) in kinetic parameter estimates and simplified metrics after PVC using VOIs delineated on PVC images (LR + HYPR). Table S4. P-values of testing (Friedman’s test) between changes in kinetic parameter estimates and simplified metrics (with and without PVC) during treatment with TKI at 7 and 28 days after treatment start. Figure S1. Time-activity curves of intralesional image noise (COV%) without and with PVC using several HYPR settings. Frames of 0–4 min (A) and 4–60 min (B) post-injection. Results of a typical mediastinal lymph node metastasis are shown. (DOCX 450 kb