Network analysis of the most highly deregulated genes.

M. T. Badr (6433574)
G. Häcker (6433577)

Open link

Publication date

March 2019

DOI

10.1371/journal.pone.0213470.g003

Publisher

Public Library of Science (PLoS)

Abstract

Shared differentially expressed genes (DEGs) (TB and RA versus controls) were integrated in NetworkAnalyst tools to visualize gene interactions. A ‘zero order’ interaction network with 57 nodes was used. The most highly ranked nodes across the dataset based on network topology measures were MEPCE (betweenness centrality = 662.8; degree = 9), and RPS4X (betweenness centrality = 294.76; degree = 8).</p