Subsets of tetramer+ SIV-specific CD8 T cells in early chronic SIV infection express the apoptosis marker PARP.
- Shengbin Li (177030)
- Joy M. Folkvord (207887)
- Katalin J. Kovacs (6495377)
- Reece K. Wagstaff (6495380)
- Gwantwa Mwakalundwa (6495383)
- Aaron K. Rendahl (102028)
- Eva G. Rakasz (49023)
- Elizabeth Connick (207890)
- Pamela J. Skinner (49026)
Publication date
April 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Representative lymph node section stained with Mamu-A*001:01/Gag CM9 tetramers (red), IgM (blue), and PARP (green) showing tetramer+ PARP+ cells and tetramer+ cells in contact with PARP+ cells. Confocal images were collected with a 20X objective and the scale bar is 100 μm and 10 μm in low- and high-magnification images respectively. (B) The percentage of tetramer+ SIV-specific CD8 T cells that were PARP+ was not significantly different between follicular and extrafollicular regions (95% CI: -0.9, 3.6; p = 0.1991).</p
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