Publication date
March 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Average values of the nominal association measures across all 4,950 SNP-pairs, together with their standard errors, over 400 repetitions.</p
Average values of the nominal association measures across all 4,950 SNP-pairs, together with their standard errors, over 400 repetitions.</p
<p><i>h</i><sup>2</sup>: variance explained by the locus.</p><p>a: in case-control samples, 50% of t...
<p>The total number of studies is denoted by <i>K</i> and <i>m</i> denotes the minor allele frequenc...
<p>Results obtained in terms of average <i>Q</i><sup>2</sup> (across 500 replicates) for scenarios a...
<p>The values in the table represent the proportions of SNPs (averaged over 10 replications) found t...
Q-Q plots of nominal association measures against their theoretical quantiles.</p
<p>Association strength 0.8 and threshold for the QTN were used. (A) The correlation coefficient m...
Comparison of (A) AUC, (B) statistical power to detect true marginal and joint risk-associated SNPs ...
<p>For the simulated datasets developed from 2-SNP models, average fraction over all 100 datasets of...
<p>For the simulated datasets developed from 3-SNP models, average fraction over all 100 datasets of...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
The incorporated annotations for association tests include one out of three informative annotations ...
<p>The average over 200 simulation runs is reported for the number of detected associations (Size), ...
<p>Simulation study 2: Mean number of pathways and SNPs selected by each model at each effect size, ...
<p>Statistically significant and replicated SNP associations at 3q25 and 4p16.</p
Average F-measures (and their standard errors) over 400 replications. A star (*) in front of the num...
<p><i>h</i><sup>2</sup>: variance explained by the locus.</p><p>a: in case-control samples, 50% of t...
<p>The total number of studies is denoted by <i>K</i> and <i>m</i> denotes the minor allele frequenc...
<p>Results obtained in terms of average <i>Q</i><sup>2</sup> (across 500 replicates) for scenarios a...
<p>The values in the table represent the proportions of SNPs (averaged over 10 replications) found t...
Q-Q plots of nominal association measures against their theoretical quantiles.</p
<p>Association strength 0.8 and threshold for the QTN were used. (A) The correlation coefficient m...
Comparison of (A) AUC, (B) statistical power to detect true marginal and joint risk-associated SNPs ...
<p>For the simulated datasets developed from 2-SNP models, average fraction over all 100 datasets of...
<p>For the simulated datasets developed from 3-SNP models, average fraction over all 100 datasets of...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
The incorporated annotations for association tests include one out of three informative annotations ...
<p>The average over 200 simulation runs is reported for the number of detected associations (Size), ...
<p>Simulation study 2: Mean number of pathways and SNPs selected by each model at each effect size, ...
<p>Statistically significant and replicated SNP associations at 3q25 and 4p16.</p
Average F-measures (and their standard errors) over 400 replications. A star (*) in front of the num...
<p><i>h</i><sup>2</sup>: variance explained by the locus.</p><p>a: in case-control samples, 50% of t...
<p>The total number of studies is denoted by <i>K</i> and <i>m</i> denotes the minor allele frequenc...
<p>Results obtained in terms of average <i>Q</i><sup>2</sup> (across 500 replicates) for scenarios a...
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