Additional file 1: of Systems metabolic engineering of Corynebacterium glutamicum for the bioproduction of biliverdin via protoporphyrin independent pathway

Figure S1. Production of porphyrin intermediates of recombinant strains with different gene combinations. Black, white and gray bar represent concentration of uroporphyrin III, protoporphyrin IX and coproporphyrin III, respectively. Protoporphyrin IX was not detected in any recombinant strains. Figure S2. Non-averaged fed-batch fermentation profiles of C. glutamicum BV004 related to the Fig. 6. a, b, and c The first, second, and third rounds of fermentation, respectively. Closed circle, bacterial cell growth; open circle, residual glucose concentration; green square, biliverdin concentration. Table S1. Calculated ΔG0′ values for the reaction related to heme biosynthesis pathway. (DOCX 419 kb