A. Mice were challenged intranasally with S. maltophilia 10 days after the last immunization. Twenty four hours after the challenge, S. maltophilia loads in lung homogenate were detected. Data are shown as the median with interquartile range. Results are representative for at least three independent experiments. ** P B) and IL-6 (C) in BALF were measured from rOmpA group and control group at 6h and 24h post-challenge. Data are shown as the mean ± SD. Results are representative for three independent experiments. * P <0.05 for the rOmpA group compared with control group (PBS) was analyzed by Mann-Whitney rank test (two-tailed).</p
<p>Lung damage was macroscopically and histologically assessed in DBA/2 mice (n = 18) on days 1, 3, ...
<p>Pulmonary cytokine concentrations after intranasal infection with 2.5×10<sup>2</sup> CFU <i>B. ps...
<p>Each dot represents one mouse. <b>A.</b> Symptom severity score (Mean ± SEM) 16 hours following i...
<p>Mice were infected intranasally with 5×10<sup>7</sup> CFU WT GBS and cytokine levels in cell-free...
<p>Mice were treated with c-di-GMP (black bars) or control c-GMP (white bars) at 24 hr prior to chal...
<p>C57BL/6 or TLR2 KO mice on the same background were intranasally inoculated with PBS (mock) or 5×...
<p>CFTR<sup>–/–</sup> mice and WT-mice were infected with 1x10<sup>5</sup> CFU of bacteria (n = 6–7)...
Wild-type mice were given broad-spectrum antibiotics or autoclaved saline. Three days after cessatio...
<p>Malnourished mice were replete for 7 days with a balanced conventional diet (BD) or BD supplement...
<p>Mice were inoculated intranasally with 750<i>B. pseudomallei</i> and sacrificed after 24, 48 and ...
Stenotrophomonas maltophilia (S. maltophilia), a multi-drug resistant opportunistic pathogen, is ass...
(A-B) Groups of 5–9 C57Bl/6J mice were challenged by intranasal instillation with 2,000 (circles) or...
<p>(A) Dynamic accumulation of inflammatory cytokines in BALF in the pneumonia model; (B) and (C) Bo...
<p>Lung cytokine (TNF-α, L-1β, IL-6, IL-10) (A–D), chemokine (KC and MIP-2) (E–F) and plasma cytokin...
<p>(A,B) Mice received intratracheal instillation of LT (550 µg/kg) or saline 1 h before intranasal ...
<p>Lung damage was macroscopically and histologically assessed in DBA/2 mice (n = 18) on days 1, 3, ...
<p>Pulmonary cytokine concentrations after intranasal infection with 2.5×10<sup>2</sup> CFU <i>B. ps...
<p>Each dot represents one mouse. <b>A.</b> Symptom severity score (Mean ± SEM) 16 hours following i...
<p>Mice were infected intranasally with 5×10<sup>7</sup> CFU WT GBS and cytokine levels in cell-free...
<p>Mice were treated with c-di-GMP (black bars) or control c-GMP (white bars) at 24 hr prior to chal...
<p>C57BL/6 or TLR2 KO mice on the same background were intranasally inoculated with PBS (mock) or 5×...
<p>CFTR<sup>–/–</sup> mice and WT-mice were infected with 1x10<sup>5</sup> CFU of bacteria (n = 6–7)...
Wild-type mice were given broad-spectrum antibiotics or autoclaved saline. Three days after cessatio...
<p>Malnourished mice were replete for 7 days with a balanced conventional diet (BD) or BD supplement...
<p>Mice were inoculated intranasally with 750<i>B. pseudomallei</i> and sacrificed after 24, 48 and ...
Stenotrophomonas maltophilia (S. maltophilia), a multi-drug resistant opportunistic pathogen, is ass...
(A-B) Groups of 5–9 C57Bl/6J mice were challenged by intranasal instillation with 2,000 (circles) or...
<p>(A) Dynamic accumulation of inflammatory cytokines in BALF in the pneumonia model; (B) and (C) Bo...
<p>Lung cytokine (TNF-α, L-1β, IL-6, IL-10) (A–D), chemokine (KC and MIP-2) (E–F) and plasma cytokin...
<p>(A,B) Mice received intratracheal instillation of LT (550 µg/kg) or saline 1 h before intranasal ...
<p>Lung damage was macroscopically and histologically assessed in DBA/2 mice (n = 18) on days 1, 3, ...
<p>Pulmonary cytokine concentrations after intranasal infection with 2.5×10<sup>2</sup> CFU <i>B. ps...
<p>Each dot represents one mouse. <b>A.</b> Symptom severity score (Mean ± SEM) 16 hours following i...