Cytokine (IFN-γ, TNF-α, IL-12p70, IL-6, IL-4 and IL-17) and chemokine (MCP-1) concentrations in whole lung homogenates following c-di-GMP treatment and intranasal challenge infection with <i>B. pertussis</i>.

<p>Mice were treated with c-di-GMP (black bars) or control c-GMP (white bars) at 24 hr prior to challenge infection. Whole lungs were removed and cytokine concentrations determined in lung homogenate supernatants at 24 hr post treatment (24PT) and days two, four and six post challenge (Day 2–6). The results shown are as the means ± SD of cytokine and chemokine concentrations detected by ELISA from 3 separate experiments and nine to twelve animals per group.