Extracellular dynamics, the mutational pathway map, and the mutant spectrum.

(A) The time evolution of virions containing the infecting strain (AGG) and each of the possible mutant codons, color coded by the amino acids they encode. (B) A map of mutational pathways leading from one codon to another. Transitions are in solid lines and transversions in dashed lines. The lines connect codons separated by a single mutation. The shades of grey indicate the number of mutations from the infecting strain, AGG. (C) The time evolution of the populations of virions grouped by the amino acid variants they contain. (D) Frequencies of the different mutants at steady state. Shown for comparison is the database value of the mutant R155K for HCV genotype 1a (orange dot) [33].