Intracellular dynamics and evolution.

(A) Time-evolution of the populations of wild-type (black) and single mutant (pink) RNA genomes in infected cells. Infection is initiated by the wild-type. Each trajectory is a realization. The three patterns where the wild-type dominates, the mutant dominates, and where the mutant rises initially but is eventually outcompeted are illustrated. (B) The averaged evolution of the populations of genomes carrying different codons following infection with AGG. The relative fitness of the genomes, determined independently [19], is in the inset and is color coded. (C), (D) The corresponding populations of replication complexes and virions released.