Morphology of Der2<sup>SCKO</sup> and S63del//Der2<sup>SCKO</sup> sciatic nerves at P28.
- Vera G. Volpi (6597452)
- Cinzia Ferri (254925)
- Ilaria Fregno (6597455)
- Ubaldo Del Carro (91152)
- Francesca Bianchi (316618)
- Cristina Scapin (564586)
- Emanuela Pettinato (217795)
- Tatiana Solda (6597458)
- M. Laura Feltri (47680)
- Maurizio Molinari (224041)
- Lawrence Wrabetz (47681)
- Maurizio D’Antonio (800388)
Publication date
April 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Transverse semithin sections from WT, Der2SCKO, S63del and S63del//Der2SCKO P28 sciatic nerves. Arrowheads indicate fibers with similar diameter for myelin thickness comparison. n = 5–6 mice/genotype. Scale bar, 10μm; 100x magnification. (B-C) Morphometric g-ratio (axon diameter/fiber diameter) analysis on P28 sciatic nerve sections. Scatter-plots of g-ratio distribution with trend lines are shown. ~1500–1700 fibers/genotype; n = 3 nerves per genotype. (D) Graph representing the frequency of myelinated axons (as percentage of all myelinated axons) per axon size interval (μm) at P28.</p
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