Additional file 11: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang
Ying Xing
Qingwei Meng
Hailing Lu
Wei Liu
Shi Yan
Yang Song
Xinyuan Xu
Jian Huang
Yue Cui
Dexin Jia
Li Cai

April 2019

Abstract Background Non-small cell lung cancer (NSCLC) is a devastating disease with a heterogeneous...

Additional file 5: of 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Jia Song (495396)
Xiaochao Zhang (6046529)
Zhibin Liao (6173411)
Huifang Liang (781781)
Liang Chu (126831)
Wei Dong (6479)
Xuewu Zhang (2310436)
Qianyun Ge (6173414)
Qiumeng Liu (6173417)
Pan Fan (6173420)
Zhanguo Zhang (3138240)
Bixiang Zhang (745204)

January 2019

Figure S4. (a, b) qRT-PCR was used to analyze in HCC HLF(a) and Bel7402(b) cells for mRNA levels of ...

Additional file 4: of 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Jia Song (495396)
Xiaochao Zhang (6046529)
Zhibin Liao (6173411)
Huifang Liang (781781)
Liang Chu (126831)
Wei Dong (6479)
Xuewu Zhang (2310436)
Qianyun Ge (6173414)
Qiumeng Liu (6173417)
Pan Fan (6173420)
Zhanguo Zhang (3138240)
Bixiang Zhang (745204)

January 2019

Figure S3. (a, b, c, d) Western blotting (left panel; a, c) and qRT-PCR (right panel; b, d) were use...

Additional file 12: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S7. EHD1 expression is not affected by activation or inhibition of the β2AR signaling pathway...

Additional file 9: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

The overlap between Î˛2AR-dependent gene expression and EHD1-regulated gene expression. (XLSX 14 kb

Additional file 10: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S5. EHD1 expression is positively correlated with β2AR signaling in NSCLC. a Analyses of TCGA...

Additional file 4: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

The association between EHD1 and vascular endothelial cell proliferation. (XLSX 25 kb

Additional file 1: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Table S1. Association between EHD1 expression and clinicopathological characteristics of NSCLC patie...

Additional file 7: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S3. EHD1 knockdown attenuates p-AKT and p-Erk expression in HUVECs. p-AKT and p-Erk expressio...

Additional file 5: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

The association between EHD1 and vascular endothelial cell migration. (XLSX 26 kb

Additional file 6: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S2. Reexpression of EHD1 promotes angiogenesis. a Western blot analysis of EHD1 expression in...

Additional file 14: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S9. Correlation of EHD1 with β2AR, VEGFA and CD31 expression and angiogenesis in HCC tissues....

Additional file 2: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S1. EHD1 overexpression is associated with poor prognosis. a, b Kaplan-Meier curves of overal...

Additional file 13: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S8. Blocking β2AR inhibited EHD1-induced VEGFA expression and angiogenesis. a Western blot an...

Additional file 8: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S4. Reexpression of EHD1 increases VEGFA expression and angiogenesis. a Western blot analysis...

Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang
Ying Xing
Qingwei Meng
Hailing Lu
Wei Liu
Shi Yan
Yang Song
Xinyuan Xu
Jian Huang
Yue Cui
Dexin Jia
Li Cai

April 2019

Abstract Background Non-small cell lung cancer (NSCLC) is a devastating disease with a heterogeneous...

Additional file 5: of 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Jia Song (495396)
Xiaochao Zhang (6046529)
Zhibin Liao (6173411)
Huifang Liang (781781)
Liang Chu (126831)
Wei Dong (6479)
Xuewu Zhang (2310436)
Qianyun Ge (6173414)
Qiumeng Liu (6173417)
Pan Fan (6173420)
Zhanguo Zhang (3138240)
Bixiang Zhang (745204)

January 2019

Figure S4. (a, b) qRT-PCR was used to analyze in HCC HLF(a) and Bel7402(b) cells for mRNA levels of ...

Additional file 4: of 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Jia Song (495396)
Xiaochao Zhang (6046529)
Zhibin Liao (6173411)
Huifang Liang (781781)
Liang Chu (126831)
Wei Dong (6479)
Xuewu Zhang (2310436)
Qianyun Ge (6173414)
Qiumeng Liu (6173417)
Pan Fan (6173420)
Zhanguo Zhang (3138240)
Bixiang Zhang (745204)

January 2019

Figure S3. (a, b, c, d) Western blotting (left panel; a, c) and qRT-PCR (right panel; b, d) were use...

Additional file 12: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S7. EHD1 expression is not affected by activation or inhibition of the β2AR signaling pathway...

Additional file 9: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

The overlap between Î˛2AR-dependent gene expression and EHD1-regulated gene expression. (XLSX 14 kb

Additional file 10: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S5. EHD1 expression is positively correlated with β2AR signaling in NSCLC. a Analyses of TCGA...

Additional file 4: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

The association between EHD1 and vascular endothelial cell proliferation. (XLSX 25 kb

Additional file 1: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Table S1. Association between EHD1 expression and clinicopathological characteristics of NSCLC patie...

Additional file 7: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S3. EHD1 knockdown attenuates p-AKT and p-Erk expression in HUVECs. p-AKT and p-Erk expressio...

Additional file 5: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating Î˛2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

The association between EHD1 and vascular endothelial cell migration. (XLSX 26 kb

Additional file 6: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S2. Reexpression of EHD1 promotes angiogenesis. a Western blot analysis of EHD1 expression in...

Additional file 14: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S9. Correlation of EHD1 with β2AR, VEGFA and CD31 expression and angiogenesis in HCC tissues....

Additional file 2: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S1. EHD1 overexpression is associated with poor prognosis. a, b Kaplan-Meier curves of overal...

Additional file 13: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S8. Blocking β2AR inhibited EHD1-induced VEGFA expression and angiogenesis. a Western blot an...

Additional file 8: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang (16292)
Ying Xing (278605)
Qingwei Meng (312005)
Hailing Lu (2541760)
Wei Liu (20030)
Shi Yan (164233)
Yang Song (88132)
Xinyuan Xu (2873600)
Jian Huang (7250)
Yue Cui (212753)
Dexin Jia (6637295)
Li Cai (3899)

April 2019

Figure S4. Reexpression of EHD1 increases VEGFA expression and angiogenesis. a Western blot analysis...

Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Ting Wang
Ying Xing
Qingwei Meng
Hailing Lu
Wei Liu
Shi Yan
Yang Song
Xinyuan Xu
Jian Huang
Yue Cui
Dexin Jia
Li Cai

April 2019

Abstract Background Non-small cell lung cancer (NSCLC) is a devastating disease with a heterogeneous...

Additional file 5: of 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Jia Song (495396)
Xiaochao Zhang (6046529)
Zhibin Liao (6173411)
Huifang Liang (781781)
Liang Chu (126831)
Wei Dong (6479)
Xuewu Zhang (2310436)
Qianyun Ge (6173414)
Qiumeng Liu (6173417)
Pan Fan (6173420)
Zhanguo Zhang (3138240)
Bixiang Zhang (745204)

January 2019

Figure S4. (a, b) qRT-PCR was used to analyze in HCC HLF(a) and Bel7402(b) cells for mRNA levels of ...

Additional file 4: of 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Jia Song (495396)
Xiaochao Zhang (6046529)
Zhibin Liao (6173411)
Huifang Liang (781781)
Liang Chu (126831)
Wei Dong (6479)
Xuewu Zhang (2310436)
Qianyun Ge (6173414)
Qiumeng Liu (6173417)
Pan Fan (6173420)
Zhanguo Zhang (3138240)
Bixiang Zhang (745204)

January 2019

Figure S3. (a, b, c, d) Western blotting (left panel; a, c) and qRT-PCR (right panel; b, d) were use...

Additional file 11: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Abstract

Extracted data

Additional file 11: of Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling

Abstract

Extracted data

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