Comparison of the modal allele size, progenitor allele length (ePAL), and degree of somatic instability (SI) from two different DNA tissue sources of the same DM1 patient.

Panel A shows the comparison of the modal allele length in the two tissues analysed. The dashed line corresponds to the line of best for the correlation. Points above the solid line indicate larger modal allele length in saliva than in blood. Panel B shows the comparison of the ePAL in the two tissues analysed. The dashed line corresponds to the line of best fit for the correlation. Points above the solid line indicate larger ePALs in saliva than in blood. Panel C shows the comparison of the degree of SI in the two tissues analysed. The dashed line corresponds to the line of best fit for the correlation. Points below the solid line indicate a lower degree of SI in saliva than in blood. Panels in D show a diagrammatic comparison of the somatic instability degree (SI) and the estimated progenitor allele length (ePAL) from two different DNA sources of the 38 DM1 patients analysed in this project. The whiskers represent the SI range for each tissue of each patient, whereas the diamonds and triangles indicate the modal allele in saliva and blood respectively. For better comparison, samples were split over three graphs according to the ePAL measured in blood.