Multimodal imaging of retinal angiomatous proliferation (RAP).

A. Fluorescein angiogram during the late venous phase shows a hyperfluorescent leaking "hot spot" superior to the foveal avascular zone, corresponding to the RAP lesion. (red circle) B. Optical coherence tomography (OCT) cross section showing a hyperreflective intraretinal lesion. (red circle) C. En face optical coherence tomography angiography (OCTA) of the deep capillary plexus (DCP), shows an abnormal vascular structure superior to the foveal avascular zone. (cyan circle) D. OCTA cross section representing the DCP slab in (C), segmented with an upper boundary 30 μm below the inner plexiform layer (IPL), and a lower boundary set at 10 μm below the outer plexiform layer (OPL), shows flow signal starting within the hyperreflective lesion arising from the DCP and traversing the outer nuclear layer (ONL) to reach the RPE. (cyan circle) E. En face OCTA of the outer avascular retina, reveals a downward-growing extension of RAP from the overlying DCP. (yellow circle) F. OCTA cross section representing the outer slab in (E), segmented with an upper boundary set 10μm below the OPL and a lower boundary set at 10 μm above Bruch's membrane, shows flow signal corresponding to the RAP lesion. (yellow circle).