The whole blood gene expression levels for a cluster of mitochondrial genes associated with oxidative phosphorylation from String 10 protein-protein interaction analysis were plotted.

Results demonstrate that levels of each gene are differentially lower in the chronic T1 compared with the acute and normal participants. In each panel, the raw, normalized, non-zero gene expression counts from DESeq analysis are displayed as a scatter plot for each cohort. Symbols indicate individual expression levels for each of the N = 64 samples. A Kruskal-Wallis 1-way ANOVA was used to examine comparisons. In all cases except MT-CYB, the expression levels were statistically significantly lower in chronic T1 patients. (A) Mitochondrial encoded NADH dehydrogenase 1 (MT-ND1) gene (H = 12.29, p = 0.0064. (B) NADH dehydrogenase 2 (MT-ND2) gene (H = 12.05, p = 0.0072). (C) NADH dehydrogenase 5 (MT-ND5) gene (H = 10.22, p = 0.0168). (D) NADH dehydrogenase 6 (MT-ND6) gene (H = 17.03, p = 0.0007). (E) Cytochrome B (MT-CYB) gene (H = 7.333, p = 0.0620). (F) Cytochrome C oxidase III (MT-CO3) gene (H = 8.146, p = 0.0431).