L'exposition durant la vie périnatale à des perturbateurs endocriniens (PE) anti-androgéniques, induit des altérations durables du système reproducteur mâle. Si leur action a été objectivée chez l’homme et l’animal, la question du seuil de toxicité reste entière, car l’exposition environnementale correspond à de faibles doses. Ici, nous exposons in utero des rats mâles à de faibles doses de flutamide: 10 mg/kg/j ; 1; 3 doses faibles selon la définition de l'OMS 0.1; 0.01; 0.001 et 0. L'exposition fœtale induit chez l’adulte (1) des altérations morphologiques à la dose 10 mg/kg/j (diminution du poids des organes du tractus génital et une diminution du compte spermatique); (2) des altérations cellulaires à partir de 1mg (augmentation de l'apo...
Abstract We previously demonstrated that the androgenic and anti-androgenic effects of endocrine dis...
testicular descent in the rat after prenatal exposure to the antiandrogen flutamid
Smoking by women during pregnancy can result in a 30–48% reduction in sperm count and testis size in...
Exposure during perinatal life to anti-androgenic endocrine disruptors (ED) induces sustained altera...
Introduction: To investigate the effects of blocking prenatal androgen with the anti-androgen flutam...
Depuis plusieurs années, des agents exogènes environnementaux appelés perturbateurs endocriniens (PE...
Les perturbateurs endocriniens (PE) font l’objet d’une controverse scientifique à l’heure actuelle c...
For several years, certain environmental chemicals known as endocrine disrupters (ED) have been susp...
For several years, certain environmental chemicals known as endocrine disruptors have been suspected...
Exposure of male Albino Swiss rats to the non-steroidal anti-androgen flutamide during the period fr...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Exposure to endocrine-disrupting compounds (EDCs) during pregnancy and early development can lead to...
Exposure to endocrine-disrupting compounds (EDCs) during pregnancy can result in negative health eff...
We have previously demonstrated that male rats exposed to stress during the last week of gestation p...
This study evaluated the effects of antiandrogen exposure during the prepubertal period on reproduct...
Abstract We previously demonstrated that the androgenic and anti-androgenic effects of endocrine dis...
testicular descent in the rat after prenatal exposure to the antiandrogen flutamid
Smoking by women during pregnancy can result in a 30–48% reduction in sperm count and testis size in...
Exposure during perinatal life to anti-androgenic endocrine disruptors (ED) induces sustained altera...
Introduction: To investigate the effects of blocking prenatal androgen with the anti-androgen flutam...
Depuis plusieurs années, des agents exogènes environnementaux appelés perturbateurs endocriniens (PE...
Les perturbateurs endocriniens (PE) font l’objet d’une controverse scientifique à l’heure actuelle c...
For several years, certain environmental chemicals known as endocrine disrupters (ED) have been susp...
For several years, certain environmental chemicals known as endocrine disruptors have been suspected...
Exposure of male Albino Swiss rats to the non-steroidal anti-androgen flutamide during the period fr...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Exposure to endocrine-disrupting compounds (EDCs) during pregnancy and early development can lead to...
Exposure to endocrine-disrupting compounds (EDCs) during pregnancy can result in negative health eff...
We have previously demonstrated that male rats exposed to stress during the last week of gestation p...
This study evaluated the effects of antiandrogen exposure during the prepubertal period on reproduct...
Abstract We previously demonstrated that the androgenic and anti-androgenic effects of endocrine dis...
testicular descent in the rat after prenatal exposure to the antiandrogen flutamid
Smoking by women during pregnancy can result in a 30–48% reduction in sperm count and testis size in...