Dans le but de maintenir leur métabolisme et leur prolifération exacerbée, les tumeurs sont dépendantes d’un apport accru en acides aminés. Afin d'optimiser cet apport, les tumeurs surexpriment certains transporteurs clés tels que l'hétérodimère multifonctionnel CD98/LAT1. CD98 (SLC3A2) agit comme co-récepteur des intégrines β et amplifie leur signalisation régulant ainsi la migration et l'adhésion cellulaire. La protéine LAT1 (SLC7A5) est quant à elle responsable du transport des acides aminés (AA) essentiels. Des études antérieures ont suggéré que la fonction CD98/intégrines du complexe est essentielle à la croissance tumorale, alors que LAT1 aurait un rôle mineur dans ce contexte. Cependant, les besoins nutritifs accrus des cellules tumo...
Abstract Background Reprogrammed energy metabolism has become an emerging hallmark of cancer in rece...
BACKGROUND L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into...
Tumor cells are known for their ability to proliferate. Nutrients are essential for rapidly growing ...
Tumours rely on external amino acids (AA) uptake to maintain their exacerbated metabolism and prolif...
The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon th...
AbstractL-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells...
Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are hig...
System L amino acid transporter 1 (LAT1) is highly expressed in various types of human cancer, and c...
The l-type amino acid transporter 1 (LAT1) is a membranous transporter that transports neutral amino...
The PI3K/Akt/mTOR pathway has been well known to interact with the estrogen receptor (ER)-pathway an...
LAT1 (SLC7A5) is a Na+ and pH-independent amino acid antiporter that regulates distribution of His a...
BACKGROUND: LAT1 (SLC7A5) is the transport competent unit of the heterodimer formed with the glycop...
Na+-independent large neutral amino acid transporters (LATs) represent the main intracellular transp...
L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor me...
Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type (l...
Abstract Background Reprogrammed energy metabolism has become an emerging hallmark of cancer in rece...
BACKGROUND L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into...
Tumor cells are known for their ability to proliferate. Nutrients are essential for rapidly growing ...
Tumours rely on external amino acids (AA) uptake to maintain their exacerbated metabolism and prolif...
The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon th...
AbstractL-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells...
Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are hig...
System L amino acid transporter 1 (LAT1) is highly expressed in various types of human cancer, and c...
The l-type amino acid transporter 1 (LAT1) is a membranous transporter that transports neutral amino...
The PI3K/Akt/mTOR pathway has been well known to interact with the estrogen receptor (ER)-pathway an...
LAT1 (SLC7A5) is a Na+ and pH-independent amino acid antiporter that regulates distribution of His a...
BACKGROUND: LAT1 (SLC7A5) is the transport competent unit of the heterodimer formed with the glycop...
Na+-independent large neutral amino acid transporters (LATs) represent the main intracellular transp...
L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor me...
Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type (l...
Abstract Background Reprogrammed energy metabolism has become an emerging hallmark of cancer in rece...
BACKGROUND L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into...
Tumor cells are known for their ability to proliferate. Nutrients are essential for rapidly growing ...