LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells
- Hayashi, Keitaro
- Jutabha, Promsuk
- Maeda, Sumiko
- Supak, Yothaisong
- Ouchi, Motoshi
- Endou, Hitoshi
- Fujita, Tomoe
- Chida, Masayuki
- Anzai, Naohiko
Publication date
November 2016
DOI Publisher
The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.Abstract
AbstractL-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma
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