Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excluding relationship with the pathogen Neisseria meningitidis. Here we report controlled human infection with genomically-defined N. lactamica and subsequent bacterial microevolution during 26 weeks of colonisation. We find that most mutations that occur during nasopharyngeal carriage are transient indels within repetitive tracts of putative phase-variable loci associated with host-microbe interactions (pgl and lgt) and iron acquisition (fetA promotor and hpuA). Recurrent polymorphisms occurred in genes associated with energy metabolism (nuoN, rssA) and the CRISPR-associated cas1. A gene encoding a large hypothetical protein was often mutated i...
BACKGROUND: Pharyngeal colonisation by the commensal bacterium Neisseria lactamica inhibits colonisa...
AbstractNeisseria meningitidis, the cause of meningococcal disease, has been the subject of sophisti...
© 2020 Green et al. Host persistence of bacteria is facilitated by mutational and recombina-torial p...
Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excl...
Carriage of Neisseria lactamica occurs naturally at high frequency in infants and low frequency in y...
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nas...
Neisseria meningitidis is a bacterium that colonises the human nasopharyngeal mucosal surface. Occas...
Background: Neisseria meningitidis is a naturally transformable, facultative pathogen colonizing the...
Some members of the physiological human microbiome occasionally cause life-threatening disease even ...
Some members of the physiological human microbiome occasionally cause life-threatening disease even ...
Asymptomatic and persistent colonization of the upper respiratory tract by Neisseria meningitidis oc...
BACKGROUND:Since 2009, increases in invasive meningococcal disease have occurred in the United Kingd...
Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human...
Neisseria meningitidis (meningococcus) can cause meningococcal disease, a rapidly progressing and of...
Joseph B, Schwarz RF, Linke B, et al. Virulence Evolution of the Human Pathogen Neisseria meningitid...
BACKGROUND: Pharyngeal colonisation by the commensal bacterium Neisseria lactamica inhibits colonisa...
AbstractNeisseria meningitidis, the cause of meningococcal disease, has been the subject of sophisti...
© 2020 Green et al. Host persistence of bacteria is facilitated by mutational and recombina-torial p...
Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excl...
Carriage of Neisseria lactamica occurs naturally at high frequency in infants and low frequency in y...
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nas...
Neisseria meningitidis is a bacterium that colonises the human nasopharyngeal mucosal surface. Occas...
Background: Neisseria meningitidis is a naturally transformable, facultative pathogen colonizing the...
Some members of the physiological human microbiome occasionally cause life-threatening disease even ...
Some members of the physiological human microbiome occasionally cause life-threatening disease even ...
Asymptomatic and persistent colonization of the upper respiratory tract by Neisseria meningitidis oc...
BACKGROUND:Since 2009, increases in invasive meningococcal disease have occurred in the United Kingd...
Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human...
Neisseria meningitidis (meningococcus) can cause meningococcal disease, a rapidly progressing and of...
Joseph B, Schwarz RF, Linke B, et al. Virulence Evolution of the Human Pathogen Neisseria meningitid...
BACKGROUND: Pharyngeal colonisation by the commensal bacterium Neisseria lactamica inhibits colonisa...
AbstractNeisseria meningitidis, the cause of meningococcal disease, has been the subject of sophisti...
© 2020 Green et al. Host persistence of bacteria is facilitated by mutational and recombina-torial p...