BACKGROUND: Pharyngeal colonisation by the commensal bacterium Neisseria lactamica inhibits colonisation by Neisseria meningitidis and has an inverse epidemiological association with meningococcal disease. The mechanisms that underpin this relationship are unclear, but could involve the induction of cross-reactive immunity. In this study, we aimed to evaluate whether colonisation with N lactamica induces N lactamica-specific B-cell responses that are cross-reactive with N meningitidis.METHODS: In this randomised, placebo-controlled, human infection trial at University Hospital Southampton Clinical Research Facility (Southampton, UK), healthy adults aged 18-45 years were randomly assigned (2:1) to receive intranasal inoculation with either 1...
The human upper respiratory tract is colonised by a diverse commensal flora that is tolerated by the...
Introduction :Neisseria lactamica is a commensal organism found in the human nasopharynx and is clos...
The upper respiratory tract commensal Neisseria lactamica (Nlac) induces protective humoral immunity...
BACKGROUND: Herd protection by meningococcal vaccines is conferred by population-level reduction of ...
Background Herd protection by meningococcal vaccines is conferred by population-level reduction of m...
Carriage of Neisseria lactamica occurs naturally at high frequency in infants and low frequency in y...
Neisseria meningitidis is a bacterium that colonises the human nasopharyngeal mucosal surface. Occas...
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nas...
Neisseria lactamica is a nonpathogenic commensal of the human upper respiratory tract that has been ...
Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excl...
Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excl...
The rationale for the present study was to determine how different species of bacteria interact with...
The normal flora that colonizes the mucosal epithelia has evolved diverse strategies to evade, modul...
Neisseria lactamica is a commensal bacteria that colonizes the human upper respiratory tract mucosa ...
The human nasopharynx contains a stable microbial ecosystem of commensal and potentially pathogenic ...
The human upper respiratory tract is colonised by a diverse commensal flora that is tolerated by the...
Introduction :Neisseria lactamica is a commensal organism found in the human nasopharynx and is clos...
The upper respiratory tract commensal Neisseria lactamica (Nlac) induces protective humoral immunity...
BACKGROUND: Herd protection by meningococcal vaccines is conferred by population-level reduction of ...
Background Herd protection by meningococcal vaccines is conferred by population-level reduction of m...
Carriage of Neisseria lactamica occurs naturally at high frequency in infants and low frequency in y...
Neisseria meningitidis is a bacterium that colonises the human nasopharyngeal mucosal surface. Occas...
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nas...
Neisseria lactamica is a nonpathogenic commensal of the human upper respiratory tract that has been ...
Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excl...
Neisseria lactamica is a harmless coloniser of the infant respiratory tract, and has a mutually-excl...
The rationale for the present study was to determine how different species of bacteria interact with...
The normal flora that colonizes the mucosal epithelia has evolved diverse strategies to evade, modul...
Neisseria lactamica is a commensal bacteria that colonizes the human upper respiratory tract mucosa ...
The human nasopharynx contains a stable microbial ecosystem of commensal and potentially pathogenic ...
The human upper respiratory tract is colonised by a diverse commensal flora that is tolerated by the...
Introduction :Neisseria lactamica is a commensal organism found in the human nasopharynx and is clos...
The upper respiratory tract commensal Neisseria lactamica (Nlac) induces protective humoral immunity...