Dietary Fat Intake and Development of Specific Breast Cancer Subtypes
- Sieri S
- Agnoli C
- Pala V
- Berrino F
- Trichopoulou A
- Benetou V
- Vasilopoulou E
- Sanchez MJ
- Chirlaque MD
- Amiano P
- Ramon Quiros J
- Ardanaz E
- Buckland G
- Masala G
- Panico S
- Grioni S
- Sacerdote C
- Tumino R
- Boutron Ruault MC
- Clavel Chapelon F
- Fagherazzi G
- Peeters PHM
- van Gils CH
- Bueno de Mesquita HB
- van Kranen HJ
- Key TJ
- Travis RC
- Khaw KT
- Wareham NJ
- Kaaks R
- Lukanova A
- Boeing H
- Schuetze M
- Sonestedt E
- Wirfaelt E
- Sund M
- Andersson A
- Chajes V
- Rinaldi S
- Romieu I
- Weiderpass E
- Skeie G
- Dagrun E
- Tjonneland A
- Halkjaer J
- Overvard K
- Merritt MA
- Cox D
- Riboli E
- Krogh V.
- CHIODINI, Paolo
DOIAbstract
We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337 327) heterogeneous cohort of women, with 10 062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER+PR+ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER-PR- disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly inc...
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