Short step synthesis of an antibiotic, 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole

金沢大学大学院自然科学研究科生理活性物質科学For evaluating the effectiveness of organic synthesis, both intellectual property factor (IPF) and application potential factor (APF) are proposed. As a representative example, a highly effective synthetic method with IPF value of 53.8 and APF value of 100 has been established starting from indigo directing toward an antibiotic, 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole, using only conventional reagents without using any protecting groups. © 2004 The Japan Institute of Heterocyclic Chemistry All rights reserved