Synthesis of analogs of wasabi phytoalexin (methyl 1-methoxyindole-3-carboxylate)

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部Syntheses of wasabi phytoalexin analogs, such as 6-bromo-5-iodo, 2-bromo-5-iodo, 6-nitro, 5-chloroacetyl, and 6-chloroacetyl congeners, are reported. An interesting effect of the 1-methoxy group on the regioselectivity of electrophilic substitution reactions on indole nucleus is observed