Synthesis of 3a-(indol-3-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole core of leptosins D-F based on nucleophilic substitution reaction on indole nucleus

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部A simple and convenient synthetic methodology for 3a-(indol-3-yl)- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole, the core structure of leptosins D-F is developed by applying nucleophilic substitution reaction of 1- hydroxytryptamines