Add to ORKGRATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atherogenesis. A causal relation relationship between gut microbiota, inflammation and atherosclerosis has not been explored previously. OBJECTIVE: Here, we investigated whether a pro-inflammatory microbiota from Caspase1-/- ( Casp1-/-) mice accelerates atherogenesis in Ldlr-/- mice. METHODS AND RESULTS: We treated female Ldlr-/- mice with antibiotics and subsequently transplanted them with fecal microbiota from Casp1-/- mice based on a co-housing approach. Autologous transplantation of fecal microbiota of Ldlr-/- mice served as control. Mice were co-housed for 8 or 13 weeks and fed chow or a high-fat cholesterol-rich (HFC) diet. Fecal samples were c...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Aim: In recent years the gut microbiome has been recognized as an important participant in the etiol...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Aim: In recent years the gut microbiome has been recognized as an important participant in the etiol...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Rationale: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
RATIONALE: Several studies have suggested a role for the gut microbiota in inflammation and atheroge...
Aim: In recent years the gut microbiome has been recognized as an important participant in the etiol...