Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, are 98% identical within their kinase domain and perform similar functions in several settings; however, they are not completely redundant and, depending on the cell type and differentiative status, they also play unique roles. We recently identified a role for GSK3B in drug resistance by demonstrating that its inhibition enables necroptosis in response to chemotherapy in p53-null drug-resistant colon carcinoma cells. We report here that, similarly to GSK3B, also GSK3A silencing/inhibition does not affect cell proliferation or cell cycle but only abolishes growth after treatment with DNA-damaging chemotherapy. In particular, blocking GSK3A impa...
Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GS...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
<div><p>Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct g...
PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug re...
PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug re...
PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug re...
Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to...
Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cel...
Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to...
Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently re...
Glycogen synthase kinase3 (GSK3) is a constitutively active serine/theronine kinasethat has two isof...
Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GS...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
<div><p>Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct g...
PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug re...
PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug re...
PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug re...
Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to...
Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cel...
Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to...
Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently re...
Glycogen synthase kinase3 (GSK3) is a constitutively active serine/theronine kinasethat has two isof...
Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GS...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...